RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function
نویسندگان
چکیده
منابع مشابه
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. Located on chromosomal 21, the RUNX1 gene is involved in many forms of c...
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RUNX1 is a member of the RUNX family of transcription factors that also includes RUNX2 and RUNX3 [1]. Early studies identified RUNX1 as a key regulator of definitive hematopoiesis and the role of RUNX1 as a tumor suppressor in leukemia is well established [1]. In more recent sequencing studies of solid tumors, molecular alterations have been identified in other cancer types, suggesting a broade...
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The RUNX gene family includes three evolutionarily conserved genes (RUNX1, RUNX2 and RUNX3) encoding transcription factors involved in cell lineage differentiation during development and various forms of cancer. The RUNX1 gene, located in chromosome 21q22, is crucial for the establishment of definite hematopoiesis and the generation of hematopoietic stem cells in the embryo. It contains a "Runt...
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Interactions between the cell cycle machinery and transcription factors play a central role in coordinating terminal differentiation and proliferation arrest. We here show that cyclin-dependent kinase 6 (Cdk6) is specifically expressed in proliferating hematopoietic progenitor cells, and that Cdk6 inhibits transcriptional activation by Runx1, but not C/EBPalpha or PU.1. Cdk6 inhibits Runx1 acti...
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The regulation of TCR rearrangements, particularly of TCRδ and TCRβ, plays a decisive role in lymphoid differentiation and oncogenic transformation. Somatic assembly of TCR loci is established through V(D)J recombination during lymphocyte development. All V, (D) and J gene segments are flanked with recombination signal sequences (RSS) which are composed of conserved heptamer and nonamer motifs ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m700074200